Prevalence of KISS1 Receptor mutations in a series of 603 patients with normosmic congenital hypogonadotrophic hypogonadism and characterization of novel mutations: a single-centre study. MANAGEMENT OF ENDOCRINE DISEASE: Reversible hypogonadotropic hypogonadism Congenital Hypogonadotropic Hypogonadism and Kallmann Syndrome: Past, Present, and Future.