Kallmann syndrome is a rare genetic disorder that is characterized by delayed or incomplete puberty along with an impaired sense of smell. This condition is caused by a deficiency in the production of certain hormones that are crucial for both puberty and the sense of smell. Individuals with Kallmann syndrome may also experience infertility due to these hormonal imbalances. Treatment typically involves hormone replacement therapy to induce puberty and address any related symptoms. Early diagnosis and appropriate management are essential in helping individuals with Kallmann syndrome lead healthy and fulfilling lives.

A good attempt by AI but some points I would like to add as a patient with Kallmann syndrome.

Hormones do not affect the sense of smell. The lack of sense of smell comes from the nerves controlling the sense of smell not being in the correct location within the olfactory bulb (“smell centre”) of the brain.

Patients with Kallmann syndrome are most likely to be infertile due to lack of gonadotropins (FSH / LH) produced by the pituitary gland. A small minority of patients with partial or incomplete Kallmann syndrome will have a low level of sperm / egg production & fertility.

Patients with Kallmann syndrome do not experience normal puberty even when on treatment. Standard hormone replacement therapy (testosterone or progesterone / oestrogen) will produce most of the secondary physical characteristics normally seen at puberty but will not induce fertility in either male or female patients.